HCID 59255084, 화합물 → HCID 59255317, 화합물

HRID 1691173노트

반응식

HRID 1691173 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][OH:14])=[CH:11][CH:10]=1>[O-2].[O-2].[Mn+4].C(OCC)(=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH:13]=[O:14])=[CH:15][CH:16]=1

참가 물질

4

반응물 1

HCID 59255084HCID 59255084, 화합물

생성물 1

HCID 59255317HCID 59255317, 화합물수율 82.2%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

To an ethyl acetate (100 mL) solution of 4-(2-pyridin-2-yl-ethyl)benzyl alcohol (3.16 g, 14.8 mmol) described in Manufacturing Example 93-1-4 was added activated manganese dioxide (45 g, 518 mmol), which was stirred for 4 hours at room temperature. The reaction mixture was filtered through a Celite pad, and washed with ethyl acetate (100 mL). The filtrate was concentrated under a reduced pressure to obtain the title compound (2.57 g, 82%).

후처리

  1. filtrationThe reaction mixture was filtered through a Celite pad
  2. washwashed with ethyl acetate (100 mL)
  3. concentrationThe filtrate was concentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-0a7dc349ad0b4456ac5ae35c43eb0adc
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153662B2

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