(2-Amino-6-methylpyridin-3-yl)methanol → 2-Amino-6-methylnicotinaldehyde

HRID 1691284노트

반응식

HRID 1691284 반응식
[NH2:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[C:4]([CH3:10])[N:3]=1>[O-2].[O-2].[Mn+4].C(Cl)Cl>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[C:4]([CH3:10])[N:3]=1

참가 물질

4

반응물 1

HCID 55281422(2-Amino-6-methylpyridin-3-yl)methanol

생성물 1

HCID 534010302-Amino-6-methylnicotinaldehyde수율 88%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

To a methylene chloride (8 mL) solution of (2-amino-6-methyl-pyridin-3-yl)methanol (379 mg, 2.74 mmol) described in Manufacturing Example 170-1-3 was added manganese (IV) dioxide (1.19 mg, 13.7 mmol) at room temperature, which was stirred for 11 hours at room temperature. The reaction mixture was filtered through a Celite pad, and the filtrate was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:2) to obtain the title compound (328 mg, 88%).

후처리

  1. filtrationThe reaction mixture was filtered through a Celite pad
  2. concentrationthe filtrate was concentrated under a reduced pressure
  3. customThe residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:2)

출처 및 근거

ORD 기록
ord-08ea6186adf5488ebe72361ad40f0e07
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153662B2

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