Water → HCID 59377681, 화합물
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[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[O:12][CH3:13].[Br:14]Br.O>CC(O)=O>[Br:14][C:6]1[CH:7]=[C:2]([F:1])[C:3]([O:12][CH3:13])=[CH:4][C:5]=1[CH2:8][C:9]([OH:11])=[O:10]참가 물질
5
실험 절차
To a solution of 4-fluoro-3-methoxyphenylacetic acid (5.0 g, 27.1 mmol) in AcOH (20 ml) was added bromine (1.5 ml, 29.8 mmol). The mixture was stirred at room temperature for three hours. Water was added and the precipitate was isolated by filtration. The white solid was washed with water and dried to give (2-bromo-4-fluoro-5-methoxy-phenyl)-acetic acid (6.21 g, 87%).
후처리
- customthe precipitate was isolated by filtration
- washThe white solid was washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-284b0afc0a1f4c049982bd6e7e3cc3dd
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08153808B2
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