1-Fluoro-4-methoxy-5-methyl-2-nitrobenzene → 2-Fluoro-5-methoxy-4-methylaniline

HRID 1691814노트

반응식

HRID 1691814 반응식
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[N+:11]([O-])=O.[H][H]>CO.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[NH2:11]

참가 물질

5

반응물 2

HCID 598501391-Fluoro-4-methoxy-5-methyl-2-nitrobenzeneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 593777852-Fluoro-5-methoxy-4-methylaniline수율 99.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1-Fluoro-4-methoxy-5-methyl-2-nitro-benzene (1.18 g, 6.4 mmol) was dissolved in 40 ml of methanol at room temperature. 10% Palladium on Carbon (200 mg) was added and the mixture was stirred under a balloon of hydrogen overnight. The mixture was filtered through celite. The filtrate was concentrated in vacuo to give 2-fluoro-5-methoxy-4-methyl-phenylamine (990 mg, quantitative) as a solid.

후처리

  1. filtrationThe mixture was filtered through celite
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-064546fbd954456e83c9eb21053b5c0c
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153809B2

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