Water → HCID 178508959, 화합물

HRID 1691835노트

반응식

HRID 1691835 반응식
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1.[Br:9]Br.O>C(O)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[Br:9]

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 1785076342-Amino-6-hydroxypyridine

생성물 1

HCID 178508959HCID 178508959, 화합물수율 52.8%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 6-amino-pyridin-2-ol (5 g, 45.4 mmol) in glacial acetic acid (60 mL) was added bromine (2.33 mL, 45.4 mmol) under Ar atmosphere. The mixture was stirred for 20 minutes, then water was added and the mixture was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (Na2SO4), filtered and concentrated to dryness to obtain crude 6-amino-5-bromo-pyridin-2-ol (4.53 g).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe combined organic extracts were washed with brine
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-5bf03174e1a1430cbfb9790ebf829c4b
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153809B2

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