(S)-2-(4-fluoro-phenyl)-2,3-dihydro-1H-pyridin-4-one → (S)-2-(4-fluoro-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid (3-bromo-6-methoxy-pyridin-2-yl)-amide

HRID 1691838노트

반응식

HRID 1691838 반응식
[Br:1][C:2]1[C:3]([N:10]=[C:11]=[O:12])=[N:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([C@@H:20]2[CH2:25][C:24](=[O:26])[CH:23]=[CH:22][NH:21]2)=[CH:16][CH:15]=1>>[Br:1][C:2]1[C:3]([NH:10][C:11]([N:21]2[CH:22]=[CH:23][C:24](=[O:26])[CH2:25][C@H:20]2[C:17]2[CH:18]=[CH:19][C:14]([F:13])=[CH:15][CH:16]=2)=[O:12])=[N:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 59377679(S)-2-(4-fluoro-phenyl)-2,3-dihydro-1H-pyridin-4-oneHCID 593777343-Bromo-2-isocyanato-6-methoxy-pyridine

생성물 1

HCID 59377722(S)-2-(4-fluoro-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid (3-bromo-6-methoxy-pyridin-2-yl)-amide

실험 절차

(S)-2-(4-fluoro-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid (3-bromo-6-methoxy-pyridin-2-yl)-amide was prepared by reaction of 3-bromo-2-isocyanato-6-methoxy-pyridine with (S)-2-(4-fluoro-phenyl)-2,3-dihydro-1H-pyridin-4-one using the procedure of step 3 of Example 1. MS (M+H) 421.

출처 및 근거

ORD 기록
ord-bb511df7f9204a93a43ec33f05b2e448
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153809B2

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