HCID 57652073, 화합물 → HCID 57652026, 화합물

HRID 1691863노트

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HRID 1691863 반응식
[C:1](OC(N1CC[C@H](NC2C=CC(N)=CN=2)C1)=O)(C)(C)C.[CH3:21][O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24].COC([C@@H]1CC[C@H](NC2C=CC([N+]([O-])=O)=CN=2)C1)=O>>[CH2:21]([O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24])[CH3:1]

참가 물질

4

반응물 3

HCID 57652073HCID 57652073, 화합물HCID 66738250HCID 66738250, 화합물HCID 66738402HCID 66738402, 화합물

생성물 1

HCID 57652026HCID 57652026, 화합물

실험 절차

With a method similar to that used for the preparation of (S)-3-(5-amino-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester above, (1R,3S)-3-(5-amino-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester was prepared by the hydrogenation of (1R,3S)-3-(5-nitro-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester. This material was directly used in the next step without further purification.

후처리

  1. customThis material was directly used in the next step without further purification

출처 및 근거

ORD 기록
ord-33f4887b9d49421089b337bea53c504d
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153644B2

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