참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Benzenemethanol, 2,6-dichloro- | HCID 27156 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | (2,6-Dichlorophenyl)methyl acetate | HCID 261530 | — |
반응 단계
Add 500 mL of dichloromethane to 100 g of 2,6-dichlorobenzyl alcohol followed by 117 mL of triethylamine. Cool the solution to 5° C. and add 65 mL of acetic anhydride. After 2.5 hr at room temperature, add another 10 mL of acetic anhydride, 20 mL of triethylamine and 0.5 g of 4-dimethylaminopyridine. Wash the organic layer with 1N HCl followed by saturated aqueous sodium bicarbonate and brine. Dry the organic layer (sodium sulfate) and evaporate to afford 131.5 g of the titled compound as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08153807B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_04 |
|---|
| ORD ID | ord-459be403d19f41e198d4c744d78b0cf8 |
|---|
| 출처 메모 | uspto-grants-2012_04 |
|---|
