Ammonia → HCID 59303060, 화합물

HRID 1692144노트

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HRID 1692144 반응식
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[C:6]([C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)[CH:5]=1.[NH3:33]>O>[C:20]([C:17]1[CH:16]=[CH:15][C:14]([S:11]([NH:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([NH2:33])=[O:2])=[CH:5][C:6]=2[C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)(=[O:13])=[O:12])=[CH:19][CH:18]=1)([CH3:22])([CH3:23])[CH3:21]

참가 물질

4

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HCID 222AmmoniaHCID 59302970HCID 59302970, 화합물

생성물 1

HCID 59303060HCID 59303060, 화합물

시약·촉매·용매 1

HCID 962Water용매

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온도
60 °C

실험 절차

A 10 mL scintillation vial was charged with 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzoic acid methyl ester (20 mg, 0.044 mmol) and 30% NH3 in H2O (1.5 mL). The reaction was heated to 60° C. and stirred overnight. The following day, the volatiles were removed in vacuo to about 200 μL at which point the solution was purified by preparative TLC to afford 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzamide as a colorless oil: MS (ES) M+H expected 442.2, found 442.4.

후처리

  1. customThe following day, the volatiles were removed in vacuo to about 200 μL at which point the solution
  2. customwas purified by preparative TLC

출처 및 근거

ORD 기록
ord-d631e684fc61427cbdd10e9e97dedefb
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153818B2

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