3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → (3,5-Dimethyl-3'-trifluoromethoxy-biphenyl-4-yl)-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone

HRID 1692396노트

반응식

HRID 1692396 반응식
Br[C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([C:9]([N:11]2[CH2:17][CH2:16][CH2:15][N:14]([CH2:18][CH2:19][OH:20])[CH2:13][CH2:12]2)=[O:10])=[C:4]([CH3:21])[CH:3]=1.BrC1C=C(C)C(C(O)=O)=C(C)C=1.N1(CCO)CCCNCC1.BrC1C=C(C)C(C(N2CCC(N3CCCC3)CC2)=O)=C(C)C=1.[F:66][C:67]([F:79])([F:78])[O:68][C:69]1[CH:70]=[C:71](B(O)O)[CH:72]=[CH:73][CH:74]=1>>[CH3:21][C:4]1[CH:3]=[C:2]([C:71]2[CH:72]=[CH:73][CH:74]=[C:69]([O:68][C:67]([F:66])([F:78])[F:79])[CH:70]=2)[CH:7]=[C:6]([CH3:8])[C:5]=1[C:9]([N:11]1[CH2:17][CH2:16][CH2:15][N:14]([CH2:18][CH2:19][OH:20])[CH2:13][CH2:12]1)=[O:10]

참가 물질

6

반응물 5

HCID 27343853-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 27365502-(1,4-Diazepan-1-yl)ethan-1-olHCID 119590064-Bromo-2,6-dimethylbenzoic acidHCID 66901599(4-Bromo-2,6-dimethyl-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanoneHCID 66901627(4-Bromo-2,6-dimethyl-phenyl)-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone

생성물 1

HCID 57580538(3,5-Dimethyl-3'-trifluoromethoxy-biphenyl-4-yl)-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone

실험 절차

In analogy to the procedure described for example 1, (4-bromo-2,6-dimethyl-phenyl)-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone (prepared from 4-bromo-2,6-dimethyl-benzoic acid and 2-[1,4]diazepan-1-yl-ethanol in analogy to the procedure described for the preparation of intermediate 1) was reacted with 3-trifluoromethoxy-phenyl boronic acid to give the title compound as light yellow amorphous solid. MS: 437.3 (MH+).

출처 및 근거

ORD 기록
ord-de415f3200804c1eadbd6c409df66318
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153805B2

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