Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4-Bromo-2,6-dimethyl-phenyl)-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone → [4,6-Dimethyl-2-(3-trifluoromethyl-phenyl)-pyrimidin-5-yl]-(4-hydroxy-[1,4']bipiperidinyl-1'-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4-Bromo-2,6-dimethyl-phenyl)-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone | HCID 44473778 | — |
| 반응물 | 4,6-Dimethyl-2-(3-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid | HCID 62744716 | — |
| 반응물 | Benzoic acid [1,4']bipiperidinyl-4-yl ester | HCID 66901535 | — |
| 반응물 | (4-Bromo-2,6-dimethyl-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 66901599 | — |
| 생성물 | [4,6-Dimethyl-2-(3-trifluoromethyl-phenyl)-pyrimidin-5-yl]-(4-hydroxy-[1,4']bipiperidinyl-1'-yl)-methanone | HCID 57580525 | — |
반응 단계
In analogy to the procedures described for intermediate 1 and for intermediate 4 B, 4,6-dimethyl-2-(3-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid (intermediate 5) was converted into its acid chloride, reacted with benzoic acid [1,4′]bipiperidinyl-4-yl ester (example 22) and subsequently saponified to give the title compound as colorless solid. MS: 463.3 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08153805B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-5d265573b39e475b87d4da89aebff45c |
| 출처 메모 | uspto-grants-2012_04 |