Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Trimethylsilyl)methylamine → 4-(dibromomethyl)-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Trimethylsilyl)methylamine | HCID 87488 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 4-(Dibromomethyl)-3-(trifluoromethyl)benzoic acid | HCID 58270971 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | tert-Butyl methyl ether | HCID 15413 | — |
| 생성물 | 4-(dibromomethyl)-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide | HCID 58270976 | — |
반응 단계
4-(dibromomethyl)-3-(trifluoromethyl)benzoic acid (18.0 g, 49.7 mmol) was suspended in CH2Cl2. 1-(Trimethylsilyl)methanamine (5.1 g, 49.7 mmol) and 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (12.5 g, 54.7 mmol) were added to the solution at 0° C. The reaction mixture was stirred at room temperature over night. The reaction mixture was diluted with t-BuOMe and washed with 2M HCl, H2O, and brine. After drying over MgSO4 and evaporation, the product was found to be 22.0 g (99%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08158560B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-c6f2792f479e4b67882f4a1bbad74980 |
| 출처 메모 | uspto-grants-2012_04 |