Acetic Acid → 4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid

HRID 1692573노트

반응식

HRID 1692573 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2([C:27]([F:30])([F:29])[F:28])[CH2:14][C:13]([C:15]3[CH:22]=[CH:21]C(C#N)=[C:17]([C:23]([F:26])([F:25])[F:24])[CH:16]=3)=[N:12][CH2:11]2)[CH:5]=[C:6]([Cl:9])[C:7]=1[Cl:8].O.[CH3:32][C:33]([OH:35])=[O:34]>OS(O)(=O)=O.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2([C:27]([F:28])([F:30])[F:29])[CH2:14][C:13]([C:15]3[CH:22]=[CH:21][C:32]([C:33]([OH:35])=[O:34])=[C:17]([C:23]([F:24])([F:25])[F:26])[CH:16]=3)=[N:12][CH2:11]2)[CH:5]=[C:6]([Cl:9])[C:7]=1[Cl:8]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 962WaterHCID 582709654-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzonitrile

생성물 1

HCID 582709924-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid수율 82%

시약·촉매·용매 1

HCID 21910475Sulfuric acid hydrate (1:1)용매

실험 절차

4-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzonitrile (0.82 g, 1.68 mmol) was dissolved in AcOH and suspended in conc. H2SO4—H2O mixture. The reaction mixture was stirred vigorously and refluxed for 26 hours. The reaction mixture was then poured to a mixture of ice and water. The resulting mixture was then extracted with EtOAc and the organic layer was washed with brine and dried over Na2SO4. The solvent was evaporated to obtain the product (0.70 g, 82%).

후처리

  1. temperaturerefluxed for 26 hours
  2. extractionThe resulting mixture was then extracted with EtOAc
  3. washthe organic layer was washed with brine
  4. dry with materialdried over Na2SO4
  5. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-a7337517cb994651b07eec0b46c29035
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158560B2

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