Bromine → 1-benzenesulfonyl-3-bromo-7-fluoro-1H-indole

HRID 1692883노트

반응식

HRID 1692883 반응식
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[F:19])[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)(O)[O-].[Na+].[Br:25]Br>C(Cl)(Cl)(Cl)Cl.C(Cl)Cl.O>[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[F:19])[C:12]([Br:25])=[CH:11]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

7

반응물 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 116877057-Fluoro-1-(phenylsulfonyl)-1H-indole

생성물 1

HCID 596035291-benzenesulfonyl-3-bromo-7-fluoro-1H-indole수율 95%

시약·촉매·용매 3

HCID 962Water용매HCID 5943Carbon Tetrachloride용매HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-benzenesulfonyl-7-fluoro-1H-indole (1.00 g, 3.63 mmol) in CCl4 (20 mL) was added a solution of saturated sodium bicarbonate (40 mL) and bromine (0.19 mL, 3.81 mmol) at room temperature. After stirring at room temperature for 16 hours, the reaction was diluted with DCM and water. The organic extract was washed with saturated sodium bicarbonate, 10% aqueous sodium thiosulfate, dried over sodium sulfate, filtered, and concentrated. The product was obtained as an off-white solid (1.22 g, 95%)

후처리

  1. extractionThe organic extract
  2. washwas washed with saturated sodium bicarbonate, 10% aqueous sodium thiosulfate
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3c5862e76e3f4feb971f97f09d7bf6a5
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158625B2

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