Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Methylthio)-1H-pyrimidin-4-one → 2-(3-(2-methylthiazol-4-yl)phenylamino)pyrimidin-4(3H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Methylthio)-1H-pyrimidin-4-one | HCID 79823 | — |
| 반응물 | 3-(2-Methyl-thiazol-4-yl)-phenylamine | HCID 736535 | — |
| 용매 | Diglyme | HCID 8150 | — |
| 생성물 | 2-(3-(2-methylthiazol-4-yl)phenylamino)pyrimidin-4(3H)-one | HCID 57780911 | 25% |
반응 단계
To 2-(methyl-thio)pyrimidine-4(3H)-one, 1, (1 g, 14.08 mmol) in diglyme (9 mL) is added 3-(2-methylthiazol-4-yl)benzenamine (3.20 g, 16.90 mmol). The resulting mixture is heated to reflux and stirred for 18 hours. A solid forms upon cooling the mixture to room temperature. The solid is washed with hexanes to afford 1.0 g (25% yield) of the desired compound. MS (ESI, pos. ion) m/z: 285 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08158641B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-522812e860dc4d1ebf26a57a44ee5a9b |
| 출처 메모 | uspto-grants-2012_04 |