2-Morpholinoethylamine → 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid (2-morpholin4-ylethyl)amide

HRID 1693423노트

반응식

HRID 1693423 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[CH:10]=[C:9]([C:11]([OH:13])=O)[NH:8][C:5]2=[CH:6][N:7]=1.[N:14]1([CH2:20][CH2:21][NH2:22])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[N:14]1([CH2:20][CH2:21][NH:22][C:11]([C:9]2[NH:8][C:5]3=[CH:6][N:7]=[C:2]([Cl:1])[CH:3]=[C:4]3[CH:10]=2)=[O:13])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

참가 물질

3

반응물 2

HCID 4082852-MorpholinoethylamineHCID 446307045-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

생성물 1

HCID 113013135-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid (2-morpholin4-ylethyl)amide

실험 절차

The title compound was prepared as outlined in EXAMPLE 1 from 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid (Preparation 18) and 2-morpholin-4-ylethylamine. The product was purified by chromatography on silica gel eluting with methanol/dichloromethane (1:19) to give the title compound as a yellow solid. δH (CD3OD): 2.54-2.60 (4H, m), 2.64 (2H, t), 3.58 (2H, t), 3.69-3.73 (4H, m), 7.05 (1H, s), 7.66 (1H, s), 8.58 (1H, s); m/z (ES+)=309 [M+H]+.

후처리

  1. customThe title compound was prepared
  2. customThe product was purified by chromatography on silica gel eluting with methanol/dichloromethane (1:19)

출처 및 근거

ORD 기록
ord-953acbf493bd468097f85f39b6f8fa86
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158622B2

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