HCID 1406457, 화합물 → HCID 57898097, 화합물
반응식
C(O[C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:7]=1[NH2:17])=[O:5])C.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=O)[C:27]2[CH:32]=[CH:31][C:30]([CH:33]([CH3:35])[CH3:34])=[CH:29][CH:28]=2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([N:25]2[C:4](=[O:5])[C:6]3[O:10][N:9]=[C:8]([C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=4)[C:7]=3[N:17]=[C:26]2[C:27]2[CH:28]=[CH:29][C:30]([CH:33]([CH3:35])[CH3:34])=[CH:31][CH:32]=2)=[CH:23][CH:24]=1참가 물질
3
실험 절차
6-(4-Chloro-phenyl)-5-(4-isopropyl-phenyl)-3-phenyl-6H-isoxazolo[4,5-d]pyrimidin-7-one is prepared as described in Example 2, using 4-amino-3-phenyl-isoxazole-5-carboxylic acid ethyl ester from step C instead of ethyl 5-amino-1-phenyl-4-pyrazole-carboxylate, and N-(4-chloro-phenyl)-4-isopropyl-benzamide instead of N-(4 bromo-phenyl)-4-methyl-benzamide; 1H NMR (CDCl3, 400 MHz) δ 8.42 (dd, 2H), 7.53 (m, 3H), 7.34 (d, 2H), 7.25 (d, 2H), 7.12 (m, 4H), 2.87 (m, 1H), 1.22 (s, 3H), 1.20 (s, 3H); HPLC-MS calculated for C26H20ClN3O2 (M+H+) 442.1. Found 442.1.
출처 및 근거
- ORD 기록
- ord-b12e262bc0a549ed81b558fd097fd0a9
- 출처 데이터셋
- uspto-grants-2012_04