Water → 3-Amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester

HRID 1694253노트

반응식

HRID 1694253 반응식
Cl.[CH3:2][O:3][C:4](=[O:23])[CH2:5][CH:6]([NH2:22])[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([F:16])[F:15])=[C:9]([O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)[CH:8]=1.O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[CH3:2][O:3][C:4](=[O:23])[CH2:5][CH:6]([NH2:22])[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([F:15])[F:16])=[C:9]([O:17][CH2:18][CH:19]2[CH2:20][CH2:21]2)[CH:8]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 669202293-amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester HCl salt

생성물 1

HCID 588000783-Amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester HCl salt (540 mg 1.5 mmol) in methylene chloride (20 ml) was added water (20 ml) and sodium carbonate (160 mg, 1.5 mmol). The mixture was stirred at room temperature for 30 min then separated in separatory funnel. The organic layer was washed with water (20 ml), brine (20 ml) and dried over magnesium sulfate. The solvent was removed in vacuo. The resulted oil was used in next step without further purification.

후처리

  1. customthen separated in separatory funnel
  2. washThe organic layer was washed with water (20 ml), brine (20 ml)
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was removed in vacuo
  5. customThe resulted oil was used in next step without further purification

출처 및 근거

ORD 기록
ord-e272828105184341a35bdf259799a8f2
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158672B2

반응 노트

불러오는 중…