Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → Methyl 4-(1-(indoline-7-carboxamido)cyclopropyl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 반응물 | N-Boc-indoline-7-carboxylic acid | HCID 14977845 | — |
| 반응물 | Methyl 4-(1-aminocyclopropyl)benzoate | HCID 45140209 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Methyl 4-(1-(indoline-7-carboxamido)cyclopropyl)benzoate | HCID 58017568 | — |
반응 단계
1-(tert-butoxycarbonyl)indoline-7-carboxylic acid (300 mg, 1.14 mmol), HATU (475 mg, 21.2 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (262 mg, 1.37 mmol) were added to acetonitrile (7.6 ml). The solution was cooled in an ice bath and DIPEA (695 ul, 3.99 mmol) was added. After 2 hr at RT, the mixture was poured into a solution of NaHCO3 (½ sat.) and washed 3 times with EtOAc. The combined organic layers were washed with brine and dried with Na2SO4. The solvent was removed and the crude mixture purified by flash chromatography on silica gel. The Boc group was removed with 1:1 TFA/DCM using the standard procedure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08158671B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-6ccbfe3566654562ad5557ca8317821b |
| 출처 메모 | uspto-grants-2012_04 |