5-(4,4-Dimethyl-cyclohex-1-enyl)-3-(4-[1,2,4]triazol-1-yl-cyclohexylamino)thiophene-2-carboxylic acid methyl ester → HCID 178499287, 화합물

HRID 1694478

반응식

HRID 1694478 반응식
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:22]2[CH2:27][CH2:26][C:25]([CH3:29])([CH3:28])[CH2:24][CH:23]=2)=[CH:8][C:9]=1[NH:10][CH:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH:21]=[N:20][CH:19]=[N:18]2)[CH2:13][CH2:12]1)=[O:4].[CH3:30][C@H:31]1[CH2:36][CH2:35][C@H:34]([C:37](Cl)=[O:38])[CH2:33][CH2:32]1>>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:22]2[CH2:27][CH2:26][C:25]([CH3:29])([CH3:28])[CH2:24][CH:23]=2)=[CH:8][C:9]=1[N:10]([C:37]([C@H:34]1[CH2:35][CH2:36][C@H:31]([CH3:30])[CH2:32][CH2:33]1)=[O:38])[CH:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH:21]=[N:20][CH:19]=[N:18]2)[CH2:13][CH2:12]1)=[O:4]

참가 물질

3

반응물 2

HCID 577954765-(4,4-Dimethyl-cyclohex-1-enyl)-3-(4-[1,2,4]triazol-1-yl-cyclohexylamino)thiophene-2-carboxylic acid methyl esterHCID 178461265HCID 178461265, 화합물

생성물 1

HCID 178499287HCID 178499287, 화합물수율 60%

실험 절차

5-(4,4-Dimethyl-cyclohex-1-enyl)-3-(4-[1,2,4]triazol-1-yl-cyclohexylamino) thiophene-2-carboxylic acid methyl ester (0.800 g, 2 mmol) was acylated with trans-4-methylcyclohexyl carboxylic acid chloride as previously described (example 1, step II) to give 5-(4,4-Dimethyl-cyclohex-1-enyl)-3-[(trans-4-methyl-cyclohexanecarbonyl)-(4-[1,2,4]triazol-1-yl-cyclohexyl)-amino]-thiophene-2-carboxylic acid methyl ester (0.640 g, 60%).

출처 및 근거

ORD 기록
ord-8a7b439a88b746c285d91ad0b8ed9b2c
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158675B2

연결된 노트

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