1-((4-Bromophenyl)sulfonyl)azetidine → 2-[[4'-(1-Azetidinylsulfonyl)-5-chloro[1,1'-biphenyl]-2-yl]oxy]-(2s)-propanoic acid

HRID 1694753노트

반응식

HRID 1694753 반응식
B([C:4]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:5]=1[O:6][C@@H:7]([CH3:11])[C:8]([OH:10])=[O:9])(O)O.Br[C:18]1[CH:23]=[CH:22][C:21]([S:24]([N:27]2[CH2:30][CH2:29][CH2:28]2)(=[O:26])=[O:25])=[CH:20][CH:19]=1>C1COCC1>[N:27]1([S:24]([C:21]2[CH:20]=[CH:19][C:18]([C:4]3[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:5]=3[O:6][C@@H:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:23][CH:22]=2)(=[O:25])=[O:26])[CH2:28][CH2:29][CH2:30]1

참가 물질

4

반응물 2

HCID 72132421-((4-Bromophenyl)sulfonyl)azetidineHCID 67277298(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid

생성물 1

HCID 117498052-[[4'-(1-Azetidinylsulfonyl)-5-chloro[1,1'-biphenyl]-2-yl]oxy]-(2s)-propanoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The title compound was prepared by the method of example 144 step (i) using the product from example 151 step (iv), 1-[(4-bromophenyl)sulfonyl]azetidine and THF as solvent. Yield 0.028 g.

출처 및 근거

ORD 기록
ord-238b2211693e4c3ab23a7914dc2149f1
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158820B2

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