Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylamine → N-(5-bromo-4-methylpyridin-2-yl)methanesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylamine | HCID 1146 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 2-Amino-5-bromo-4-methylpyridine | HCID 817695 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(5-bromo-4-methylpyridin-2-yl)methanesulfonamide | HCID 67280818 | — |
반응 단계
5-Bromo-4-methylpyridin-2-amine (1.56 g) was dissolved in DCM (40 ml), trimethylamine (1.4 ml) added, followed by methanesulfonyl chloride (1.9 g) and the mixture stirred for 20 min. The solution was washed with water, dried (MgSO4) and evaporated. The residue was dissolved in THF, treated with TBAF, stirred for 16 h and evaporated. The residue was purified by chromatography on silica eluting with 27% EtOAc/isohexane. Yield 1.3 g. Carried forward to step (ii) without characterisation.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08158820B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-e6ea66330efc4d8e98d63fafb5141d8a |
| 출처 메모 | uspto-grants-2012_04 |