Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N-(5-bromo-4-methylpyridin-2-yl)methanesulfonamide | HCID 67280818 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide | HCID 67280607 | — |
반응 단계
The product from step (i) (2.23 g), potassium carbonate (2.33 g) and methyl iodide (0.7 ml) were stirred in DMF (20 ml) for 20 h. The reaction was quenched with water, extracted with EtOAc, dried (MgSO4) and evaporated. The residue was purified by chromatography on silica eluting with 30% EtOAc/isohexane. Yield 1.5 g. Carried forward to step (ii) without characterisation.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08158820B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-162851ddd35c48c4be538806b1fc5bdf |
| 출처 메모 | uspto-grants-2012_04 |