(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid → 2-[4-Chloro-2-[4-methyl-6-[methyl(methylsulfonyl)amino]-3-pyridinyl]phenoxy]-(2s)-propanoic acid

HRID 1694763

반응식

HRID 1694763 반응식
Br[C:2]1[C:3]([CH3:14])=[CH:4][C:5]([N:8]([CH3:13])[S:9]([CH3:12])(=[O:11])=[O:10])=[N:6][CH:7]=1.B([C:18]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:19]=1[O:20][C@@H:21]([CH3:25])[C:22]([OH:24])=[O:23])(O)O>>[Cl:30][C:28]1[CH:27]=[CH:26][C:19]([O:20][C@@H:21]([CH3:25])[C:22]([OH:24])=[O:23])=[C:18]([C:2]2[CH:7]=[N:6][C:5]([N:8]([CH3:13])[S:9]([CH3:12])(=[O:11])=[O:10])=[CH:4][C:3]=2[CH3:14])[CH:29]=1

참가 물질

3

반응물 2

HCID 67277298(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acidHCID 67280607N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide

생성물 1

HCID 583336512-[4-Chloro-2-[4-methyl-6-[methyl(methylsulfonyl)amino]-3-pyridinyl]phenoxy]-(2s)-propanoic acid

실험 절차

The title compound was prepared by the method of example 155 using the product from step (ii) and the product from example 151 step (iv). Yield 0.125 g.

출처 및 근거

ORD 기록
ord-28c6aaf17ecc4e7ead3f0558f57bb518
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158820B2

연결된 노트

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