Ethyl 3-(4-aminophenyl)acrylate → Ethyl 3-(4-aminophenyl)propanoate

HRID 16948노트

반응식

HRID 16948 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1>C(O)C.[Pd]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 97826Ethyl 3-(4-aminophenyl)acrylate

생성물 1

HCID 10442595Ethyl 3-(4-aminophenyl)propanoate수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of ethyl 3-(4-aminophenyl)acrylate (1.5 g) and 10% Pd on activated carbon (0.3 g) in ethanol (20 ml) was hydrogenated at 30 psi for 18 h and filtered over Celite. Removal of the volatiles in vacuo provided ethyl 3-(4-aminophenyl)propionate (1.5 g).

후처리

  1. filtrationfiltered over Celite
  2. customRemoval of the volatiles in vacuo

출처 및 근거

ORD 기록
ord-3de014b2e9044c0ea92fc37139d02a8d
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737283B2

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