Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → 4-(2-Amino-8-(3-(n-(+)-biotinyl-6-aminocaproyl)-aminopropyl)-9h-purin-6-yloxymethyl)-benzyl-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | HCID 178508950 | HCID 178508950 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-(2-Amino-8-(3-(n-(+)-biotinyl-6-aminocaproyl)-aminopropyl)-9h-purin-6-yloxymethyl)-benzyl-amine | HCID 178509863 | — |
반응 단계
Trifluoroacetamide 49 (Example 32, 15.1 mg, 0.019 mmol) are dissolved in 1 mL methanol, and 2 mL methylamine (33% in ethanol) are added. The reaction mixture is stirred at room temperature for 48 h and all volatiles are removed in vacuo. The product is used without further purification. MS (ESI) m/z 667.5 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08163479B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-6a442575b20c422eaabb803b44b96fad |
| 출처 메모 | uspto-grants-2012_04 |