Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propionitrile → 2-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)propionitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propionitrile | HCID 7854 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Methyl 4-(trifluoromethyl)benzoate | HCID 520447 | — |
| 반응물 | HCID 178418806 | HCID 178418806 | — |
| 생성물 | 2-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)propionitrile | HCID 43157266 | 96% |
반응 단계
The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 4-trifluoromethyl-benzoic acid methyl ester (3.0 g, 14.7 mmol, 1.0 eq), NaH (1.2 g, 29.4 mmol, 2.0 eq) and propionitrile (4.9 mL, 69.4 mmol, 4.7 eq). The crude product was extracted with DCM and used in the following step without further purification (3.2 g, yield: 96%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08163729B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-bd720de13d4141079f412edd57df2be6 |
| 출처 메모 | uspto-grants-2012_04 |