Methanol → Methyl 4-hydroxy-2-(trifluoromethyl)benzoate

HRID 1695186노트

반응식

HRID 1695186 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.S(=O)(=O)(O)O.[CH3:20]O>>[CH3:20][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[CH:3][C:4]=1[C:11]([F:12])([F:13])[F:14]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 27751114-Hydroxy-2-(trifluoromethyl)benzoic acid

생성물 1

HCID 23109247Methyl 4-hydroxy-2-(trifluoromethyl)benzoate

실험 절차

4-hydroxy-2-trifluoromethyl-benzoic acid (5.0 g, 24.0 mmol) was dissolved in MeOH (50 mL) and a catalytic quantity of sulfuric acid was added. The mixture was refluxed overnight, after which the solvent was evaporated under reduced pressure; the crude was dissolved in DCM and washed with saturated NaHCO3. The organic phase was dried and evaporated under reduced pressure, and the product was used without further purification.

후처리

  1. temperatureThe mixture was refluxed overnight
  2. customafter which the solvent was evaporated under reduced pressure
  3. dissolutionthe crude was dissolved in DCM
  4. washwashed with saturated NaHCO3
  5. customThe organic phase was dried
  6. customevaporated under reduced pressure
  7. customthe product was used without further purification

출처 및 근거

ORD 기록
ord-6e1ce4f2d0e54b0f8fa8889f817ad51e
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163729B2

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