Ethyl Acetate → HCID 178507285, 화합물

HRID 1695192노트

반응식

HRID 1695192 반응식
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.CCO[C:10]([CH3:12])=O>>[N:1]1[CH:12]=[CH:10][CH:5]=[CH:6][C:2]=1[C:5]1[CH:6]=[C:2]([NH2:1])[NH:3][N:4]=1

참가 물질

3

반응물 2

HCID 8857Ethyl AcetateHCID 178418806HCID 178418806, 화합물

생성물 1

HCID 178507285HCID 178507285, 화합물수율 60%

반응 조건

온도
80 °C

실험 절차

The product was prepared according to general procedure for aminopyrazole synthesis (route A2). The crude product was dissolved in EtOAc, washed with NaHCO3, dried and evaporated. NMR analysis showed that a major portion of the crude mixture was still in the opened form: the mixture was then dissolved in CH3COOH and heated at 80° C. overnight, to allow for ring closure of the opened form. The product was then recovered as the acylated form, which was de-acylated stirring with HCl 6N at 60° C. overnight obtaining the title product (0.816 g, yield 60%).

후처리

  1. customThe product was prepared
  2. washwashed with NaHCO3
  3. customdried
  4. customevaporated
  5. dissolutionthe mixture was then dissolved in CH3COOH
  6. customThe product was then recovered as the acylated form, which

출처 및 근거

ORD 기록
ord-e1e270f83c994c5abcdef3e8f8684f46
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163729B2

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