HCID 17887686, 화합물 → 3-(Difluoromethoxy)-β-oxobenzenepropanenitrile

반응식

[NH2:1][C:2]1[CH:6]=CNN=1.COC(=O)C1C=CC(OCC2CC2)=C(Cl)C=1.CO[C:25](=[O:36])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH:33]([F:35])[F:34])[CH:27]=1>>[F:35][CH:33]([F:34])[O:32][C:28]1[CH:27]=[C:26]([C:25](=[O:36])[CH2:6][C:2]#[N:1])[CH:31]=[CH:30][CH:29]=1

참가 물질

반응물 3

HCID 17887686HCID 17887686, 화합물

HCID 67015924HCID 67015924, 화합물

HCID 178418806HCID 178418806, 화합물

생성물 1

HCID 431238303-(Difluoromethoxy)-β-oxobenzenepropanenitrile

실험 절차

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1 bis) from 3-difluoromethoxy-benzoic acid methyl ester (1.5 g, 7.4 mmol, 1.0 eq). The crude was precipitated by addition of aqueous HCl to give the product which was used directly for the next step.