Formate → HCID 178462496, 화합물

HRID 1695239노트

반응식

[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:13]=[C:14]([NH2:17])[NH:15][N:16]=2)=[CH:4]1)[CH3:2].[N:18]1([CH2:23][CH2:24][CH2:25][C:26](O)=[O:27])[CH2:22][CH2:21][CH2:20][CH2:19]1.C([O-])=O>>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:13]=[C:14]([NH:17][C:26](=[O:27])[CH2:25][CH2:24][CH2:23][N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)[NH:15][N:16]=2)=[CH:4]1)[CH3:2]

참가 물질

반응물 3

HCID 283Formate

HCID 148556811-Pyrrolidinebutanoic acid

HCID 178462497HCID 178462497, 화합물

생성물 1

HCID 178462496HCID 178462496, 화합물수율 42.1%

실험 절차

The product was prepared according to the general synthetic method for the synthesis of ω-amino-alkanoic acid (1H-pyrazol-3-yl-5-aryl)-amides via the amino acid route, starting from 5-(1-ethyl-1H-indol-3-yl)-2H-pyrazol-3-ylamine (99.0 mg, 0.5 mmol, 1.0 eq) and 4-pyrrolidin-1-yl-butyric acid (118 mg, 0.75 mmol). The crude product was purified via preparative HPLC; the title product (77.0 mg, 42% yield) was obtained as formate salt.

후처리

customThe product was prepared
customThe crude product was purified via preparative HPLC

출처 및 근거

ORD 기록: ord-e97dce1c27f3412ea599d8081d8e3495
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08163729B2

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