Methanol → Methyl 2-(difluoromethoxy)benzoate

HRID 1695245노트

반응식

HRID 1695245 반응식
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].S(=O)(=O)(O)O.[CH3:19]O>>[CH3:19][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=1[O:3][CH:2]([F:13])[F:1]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 20633482-(Difluoromethoxy)benzoic acid

생성물 1

HCID 7018382Methyl 2-(difluoromethoxy)benzoate수율 87%

실험 절차

2.0 g of 2-difluoromethoxy-benzoic acid (10.6 mmol, 1.0 eq) were dissolved in MeOH (15 mL) and a catalytic quantity of sulfuric acid was added; the mixture was heated at reflux overnight. The solvent was then evaporated and the residue was dissolved in DCM and washed with saturated NaHCO3. The organic phase was dried and evaporated to give 1.9 g of title product (yield 87%).

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux overnight
  3. customThe solvent was then evaporated
  4. dissolutionthe residue was dissolved in DCM
  5. washwashed with saturated NaHCO3
  6. customThe organic phase was dried
  7. customevaporated

출처 및 근거

ORD 기록
ord-efde82da3b744d7a978bcc6d18f39944
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163729B2

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