Ethanolamine → 5-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid (2-hydroxyethyl)-amide

HRID 1695369노트

반응식

CO[C:3]([C:5]1[NH:6][N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=[O:4].[CH2:22]([CH2:24][NH2:25])[OH:23]>>[OH:23][CH2:22][CH2:24][NH:25][C:3]([C:5]1[NH:6][N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=[O:4]

참가 물질

반응물 2

HCID 700Ethanolamine

HCID 66643879HCID 66643879, 화합물

생성물 1

HCID 595684365-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid (2-hydroxyethyl)-amide수율 91%

실험 절차

As described for example 27, 5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (110 mg, 0.38 mmol) was converted, using ethanolamine instead of L-alaninol, to the title compound (110 mg, 91%) which was obtained as a colorless oil. MS: m/e=323.2 [M+H]+.

출처 및 근거

ORD 기록: ord-9b02f642e40d46b699ee974c21d55510
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08163728B2

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