1,1-Dimethylhydrazine → 5-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid N',N'-dimethyl-hydrazide

HRID 1695415노트

반응식

HRID 1695415 반응식
CO[C:3]([C:5]1[N:6]([CH3:25])[N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=[O:4].[CH3:26][N:27]([CH3:29])[NH2:28]>>[CH3:26][N:27]([CH3:29])[NH:28][C:3]([C:5]1[N:6]([CH3:25])[N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=[O:4]

참가 물질

3

반응물 2

HCID 59761,1-DimethylhydrazineHCID 666436965-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester

생성물 1

HCID 595684485-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid N',N'-dimethyl-hydrazide수율 94%

실험 절차

As described for example 81c, 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (73 mg, 0.21 mmol) was converted, using N,N-dimethylhydrazine instead of morpholine, to the title compound (74 mg, 94%) which was obtained as a colorless oil. MS: m/e=375.2 [M+H]+.

출처 및 근거

ORD 기록
ord-5b20d99c55e04df1b65ab1c9bde01598
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163728B2

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