1-methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-1H-pyrazole-3-carboxylic acid methyl ester → HCID 66646207, 화합물

HRID 1695465

반응식

HRID 1695465 반응식
CO[C:3]([C:5]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[N:7]([CH3:25])[N:6]=1)=[O:4].C[O:27][C:28]([C:30]1[CH:34]=C(OCC2C(C3C=CC=CN=3)=NOC=2C)N(C)[N:31]=1)=O>>[OH:27][CH2:28][C@@H:30]([NH:31][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[N:7]([CH3:25])[N:6]=1)=[O:4])[CH3:34]

참가 물질

3

반응물 2

HCID 666463331-methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-1H-pyrazole-3-carboxylic acid methyl esterHCID 66646478HCID 66646478, 화합물

생성물 1

HCID 66646207HCID 66646207, 화합물수율 59%

실험 절차

As described for example 114d, 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.29 mmol), instead of 1-methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-1H-pyrazole-3-carboxylic acid methyl ester, was converted, to the title compound (66 mg, 59%) which was obtained as a colorless oil. MS: m/e=390.1 [M+H]+.

출처 및 근거

ORD 기록
ord-3c1549e1cbfd469cb18cb13befcd1c9e
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163728B2

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