Ethanamine, 2,2,2-trifluoro- → HCID 49793045, 화합물

HRID 1695477노트

반응식

HRID 1695477 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12](/[CH:13]=[CH:14]/[C:15]3[CH:16]=[C:17]([C:21](O)=[O:22])[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[F:25][C:26]([F:30])([F:29])[CH2:27][NH2:28]>>[F:25][C:26]([F:30])([F:29])[CH2:27][NH:28][C:21]([C:17]1[N:18]([CH3:20])[N:19]=[C:15](/[CH:14]=[CH:13]/[C:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[N:9][O:10][C:11]=2[CH3:24])[CH:16]=1)=[O:22]

참가 물질

3

반응물 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 66643882HCID 66643882, 화합물

생성물 1

HCID 49793045HCID 49793045, 화합물수율 64%

실험 절차

As described for example 122, 5-{(E)-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-vinyl}-2-methyl-2H-pyrazole-3-carboxylic acid was converted, using 2,2,2-trifluoroethylamine instead of isopropylamine, to the title compound (30 mg, 64%) which was obtained as a white solid. MS: m/e=409.0 [M+H]+.

출처 및 근거

ORD 기록
ord-8e1c6c09a5314f04b2885a4297349fc5
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163728B2

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