Cyclopropanecarbonyl chloride → HCID 178488341, 화합물

HRID 1695595노트

반응식

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH:11]([NH:13][C:14]1[O:15][CH2:16][C:17]3[CH:23]=[C:22]([NH2:24])[CH:21]=[CH:20][C:18]=3[N:19]=1)[CH2:10][CH2:9][CH2:8]2.[CH:25]1([C:28](Cl)=[O:29])[CH2:27][CH2:26]1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH:11]([NH:13][C:14]1[O:15][CH2:16][C:17]3[CH:23]=[C:22]([NH:24][C:28]([CH:25]4[CH2:27][CH2:26]4)=[O:29])[CH:21]=[CH:20][C:18]=3[N:19]=1)[CH2:10][CH2:9][CH2:8]2

참가 물질

반응물 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 178488336HCID 178488336, 화합물

생성물 1

HCID 178488341HCID 178488341, 화합물수율 97.1%

실험 절차

Prepared from rac-N2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 22) (162 mg, 0.50 mmol, HPLC 1.090 min) and cyclopropanecarbonyl chloride (53 ul, 0.55 mmol) according to the procedure described for Example 17. Obtained the title compound as an off-white solid (190 mg, 90%, HPLC 1.479 min 93%), MS (ISP) m/e=392.2 [(M+H)+].

출처 및 근거

ORD 기록: ord-91e2dcfc71a04439b0e492342aeab453
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08163740B2

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