Piperidine-1-sulfonyl chloride → HCID 178488359, 화합물

반응식

[CH3:1][O:2][C:3]1[C:8]2[CH:9]([NH:12][C:13]3[O:14][CH2:15][C:16]4[CH:22]=[C:21]([NH2:23])[CH:20]=[CH:19][C:17]=4[N:18]=3)[CH2:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[N:24]1([S:30](Cl)(=[O:32])=[O:31])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH3:1][O:2][C:3]1[C:8]2[CH:9]([NH:12][C:13]3[O:14][CH2:15][C:16]4[CH:22]=[C:21]([NH:23][S:30]([N:24]5[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]5)(=[O:32])=[O:31])[CH:20]=[CH:19][C:17]=4[N:18]=3)[CH2:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 11298344Piperidine-1-sulfonyl chloride

HCID 178488337HCID 178488337, 화합물

생성물 1

HCID 178488359HCID 178488359, 화합물수율 48%

실험 절차

Prepared from rac-N2-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 6) (100 mg, 0.321 mmol) and piperidine-1-sulfonyl chloride (65 mg, 0.353 mmol) according to the procedure described for Example 27. Obtained the title compound as a light red foam (70 mg, 48%), MS (ISP) m/e=459.3 [(M+H)+].

출처 및 근거

ORD 기록: ord-011c960b3f7a491ea2cacdd5893ad4ce
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08163740B2

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