Morpholine-4-sulfonyl chloride → HCID 178488360, 화합물

반응식

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[O:14][CH2:15][C:16]3[CH:22]=[C:21]([NH2:23])[CH:20]=[CH:19][C:17]=3[N:18]=1)[CH2:9][CH2:8]2.[N:24]1([S:30](Cl)(=[O:32])=[O:31])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[O:14][CH2:15][C:16]3[CH:22]=[C:21]([NH:23][S:30]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)(=[O:32])=[O:31])[CH:20]=[CH:19][C:17]=3[N:18]=1)[CH2:9][CH2:8]2

참가 물질

반응물 2

HCID 12798265Morpholine-4-sulfonyl chloride

HCID 178488335HCID 178488335, 화합물

생성물 1

HCID 178488360HCID 178488360, 화합물수율 54%

실험 절차

Prepared from rac-N2-(7-methoxy-indan-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 10) (100 mg, 0.323 mmol) and morpholin-4-sulfonyl chloride (66 mg, 0.356 mmol) according to the procedure described for Example 27. Obtained the title compound as a light yellow foam (80 mg, 54%), MS (ISP) m/e=459.2 [(M+H)+].

출처 및 근거

ORD 기록: ord-efcb8d1f52b04987990a1c301ddaeeaa
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08163740B2

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