Cyclopropanecarbonyl chloride → HCID 178521736, 화합물

HRID 1695647노트

반응식

HRID 1695647 반응식
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]([NH:11][C:12]2[O:13][CH2:14][C:15]3[CH:21]=[C:20]([NH2:22])[CH:19]=[CH:18][C:16]=3[N:17]=2)[CH2:3][CH2:2]1.[CH:23]1([C:26](Cl)=[O:27])[CH2:25][CH2:24]1>>[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]([NH:11][C:12]2[O:13][CH2:14][C:15]3[CH:21]=[C:20]([NH:22][C:26]([CH:23]4[CH2:25][CH2:24]4)=[O:27])[CH:19]=[CH:18][C:16]=3[N:17]=2)[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 178507252HCID 178507252, 화합물

생성물 1

HCID 178521736HCID 178521736, 화합물수율 50%

실험 절차

Prepared from rac-N2-chroman-4-yl-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 75) (295 mg, 1.0 mmol, HPLC 0.699 min) and cyclopropanecarbonyl chloride (115 mg, 0.55 mmol) according to the procedure described for Example 27. Obtained the title compound as an off-white foam (100 mg, 28%, HPLC 1.353 min), MS (ISP) m/e=364.3 [(M+H)+].

출처 및 근거

ORD 기록
ord-2907ef8b7fcf4b2dbf1486dad6884ac3
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163740B2

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