Methanesulfonyl chloride → HCID 178488352, 화합물

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[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[O:14][CH2:15][C:16]3[CH:22]=[C:21]([NH2:23])[CH:20]=[CH:19][C:17]=3[N:18]=1)[CH2:9][CH2:8]2.[CH3:24][S:25](Cl)(=[O:27])=[O:26]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[O:14][CH2:15][C:16]3[CH:22]=[C:21]([NH:23][S:25]([CH3:24])(=[O:27])=[O:26])[CH:20]=[CH:19][C:17]=3[N:18]=1)[CH2:9][CH2:8]2

참가 물질

반응물 2

HCID 31297Methanesulfonyl chloride

HCID 178488335HCID 178488335, 화합물

생성물 1

HCID 178488352HCID 178488352, 화합물수율 43.4%

실험 절차

Prepared from rac-N2-(7-methoxy-indan-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 10) (155 mg, 0.50 mmol, HPLC 0.776 min) and methanesulfonyl chloride (43 ul, 0.55 mmol) according to the procedure described for Example 27. Obtained the title compound as a light brown solid (84 mg, 43%, HPLC 1.178 min), MS (ISP) m/e=388.3 [(M+H)+].

출처 및 근거

ORD 기록: ord-64e5cb658f594e02808dfb6188100db8
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08163740B2

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