3,3-Dimethylbutylamine → HCID 178444764, 화합물

HRID 1695930

반응식

HRID 1695930 반응식
[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:11]=2[CH:12]=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:19][C:20]([CH3:25])([CH3:24])[CH2:21][CH2:22][NH2:23]>C1(C)C=CC=CC=1>[CH3:19][C:20]([CH3:25])([CH3:24])[CH2:21][CH2:22]/[N:23]=[CH:12]/[C:11]1[CH:14]=[CH:15][CH:16]=[C:17]([F:18])[C:10]=1[NH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 197093,3-DimethylbutylamineHCID 577744132-(2-(Piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde

생성물 1

HCID 178444764HCID 178444764, 화합물수율 95.9%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Crude 2-(2-(piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde (372 mg, 1.486 mmol) and 3,3-dimethylbutan-1-amine (225.6 mg, 300.0 μL, 2.229 mmol) were stirred in toluene (7 mL) with 4A MS at RT overnight. The mixture was filtered and the volatiles were removed on rotary evaporator at 40° C. to give 475 mg of crude 2-((E)-(3,3-dimethylbutylimino)methyl)-6-fluoro-N-(2-(piperidin-1-yl)ethyl)benzenamine which was used directly in the next step.

후처리

  1. filtrationThe mixture was filtered
  2. customthe volatiles were removed on rotary evaporator at 40° C.

출처 및 근거

ORD 기록
ord-a3061cb10b7e44e583edfa5987822f99
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163737B2

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