참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3,3-Dimethylbutylamine | HCID 19709 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | HCID 57774415 | HCID 57774415 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | HCID 178444765 | HCID 178444765 | — |
반응 단계
2-(2-Morpholinoethylamino)-3-fluorobenzaldehyde (495 mg, 1.962 mmol), 3,3-dimethylbutan-1-amine (400 μL, 2.973 mmol), and MgSO4 were added to toluene (15 mL) and the reaction stirred in a 70° C. oil bath overnight. The oil bath temperature was raised to 100° C. for 2.5 hours, then heat was removed, solvent and volatiles removed under high vacuum on a rotary evaporator at 35° C. to give 2-((E)-(3,3-dimethylbutylimino)methyl)-6-fluoro-N-(2-morpholinoethyl)benzenamine. The crude material was carried on to the next reaction. FIA: 336.49 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08163737B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_04 |
|---|
| ORD ID | ord-f3faa93ca66a43a1bb7ed6934ae20f26 |
|---|
| 출처 메모 | uspto-grants-2012_04 |
|---|
