3,3-Dimethylbutylamine → N-(2-(3,3-Difluoropyrrolidin-1-yl)-3-fluorobenzylidene)-3,3-dimethylbutan-1-amine

HRID 1695947

반응식

HRID 1695947 반응식
[F:1][C:2]1([F:16])[CH2:6][CH2:5][N:4]([C:7]2[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:8]=2[CH:9]=O)[CH2:3]1.[CH3:17][C:18]([CH3:23])([CH3:22])[CH2:19][CH2:20][NH2:21]>C1(C)C=CC=CC=1>[F:1][C:2]1([F:16])[CH2:6][CH2:5][N:4]([C:7]2[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:8]=2[CH:9]=[N:21][CH2:20][CH2:19][C:18]([CH3:23])([CH3:22])[CH3:17])[CH2:3]1

참가 물질

4

반응물 2

HCID 197093,3-DimethylbutylamineHCID 577744763-Fluoro-2-(3,3-difluoropyrrolidin-1-yl)benzaldehyde

생성물 1

HCID 57774377N-(2-(3,3-Difluoropyrrolidin-1-yl)-3-fluorobenzylidene)-3,3-dimethylbutan-1-amine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2-(3,3-Difluoropyrrolidin-1-yl)-3-fluorobenzaldehyde (400 mg, 1.745 mmol) was taken in toluene (15 mL) and 3,3-dimethylbutan-1-amine (176.6 mg, 234.8 μL, 1.745 mmol) was added. The reaction mixture was refluxed overnight with a Dean Stark trap to remove the water. The reaction mixture was then concentrated and used in the next step without further purification.

후처리

  1. temperatureThe reaction mixture was refluxed overnight with a Dean Stark trap
  2. customto remove the water
  3. concentrationThe reaction mixture was then concentrated
  4. customused in the next step without further purification

출처 및 근거

ORD 기록
ord-6f87a974a25e48bb917e3f4d0fb7e90f
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163737B2

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