참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl 3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate | HCID 31090 | — |
| 반응물 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Lithium benzomorpholine-2-carboxylate | HCID 69210254 | — |
반응 단계
A solution of lithium hydroxide monohydrate (1.43 g, 34.2 mmol) in water (50 mL) was added to a solution of ethyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate (3.55 g, 17.1 mmol) in dioxane (50 mL), and the mixture was stirred at 25° C. for 21 h. The reaction mixture was concentrated to afford the title compound. MS m/z: 180 (M+1 of acid).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08163766B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_04 |
|---|
| ORD ID | ord-895bb72e5b2d48cd8f87cbc0856bbb9c |
|---|
| 출처 메모 | uspto-grants-2012_04 |
|---|
