Dichloromethane → Cyclopentyl-1-cyclopentyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

HRID 1696305

반응식

HRID 1696305 반응식
[O:1]=[C:2]1[NH:7][N:6]=[C:5]([C:8]([OH:10])=[O:9])[CH:4]=[CH:3]1.[CH:11]1(I)[CH2:15][CH2:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+].C(Cl)Cl>CN(C=O)C>[CH:11]1([O:9][C:8]([C:5]2[CH:4]=[CH:3][C:2](=[O:1])[N:7]([CH:11]3[CH2:15][CH2:14][CH2:13][CH2:12]3)[N:6]=2)=[O:10])[CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 11430Potassium CarbonateHCID 73784IodocyclopentaneHCID 3059706-Hydroxypyridazine-3-carboxylic Acid

생성물 1

HCID 66845103Cyclopentyl-1-cyclopentyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

6-Oxo-1,6-dihydropyridazine-3-carboxylic acid (1 g, 7.14 mmol) was stirred with cyclopentyl iodide (2.05 ml, 17.8 mmol) and potassium carbonate (3 g, 21.4 mmol) in 15 ml DMF for 14 h at room temperature. 50 ml CH2Cl2 was added and the reaction mixture was filtered. The filtrate was concentrated and the title compound was purified by prep HPLC. Yield: 20 mg (0.072 mmol, 1%, MS m/z: 277(100%, M+1)).

후처리

  1. filtrationthe reaction mixture was filtered
  2. concentrationThe filtrate was concentrated
  3. customthe title compound was purified by prep HPLC

출처 및 근거

ORD 기록
ord-b0df505392df4751b6a9f468639da464
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163766B2

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