HCID 58011039, 화합물 → 3-[5-Amino-3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]benzonitrile

HRID 1696425노트

반응식

HRID 1696425 반응식
[NH2:1][C:2]1[N:6]([C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=2)[C:10]([NH2:12])=O)[N:5]=[C:4]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:3]=1>O=S(Cl)Cl>[NH2:1][C:2]1[N:6]([C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=2)[C:10]#[N:12])[N:5]=[C:4]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:3]=1

참가 물질

3

반응물 1

HCID 58011039HCID 58011039, 화합물

생성물 1

HCID 435430033-[5-Amino-3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]benzonitrile수율 73%

시약·촉매·용매 1

HCID 24386Thionyl Chloride용매

실험 절차

A solution of 3-(5-amino-3-t-butyl-1H-pyrazol-1-yl)benzamide (5.2 g, 20 mmol) in SOCl2 (50 mL) was heated at reflux for 6 h. After removal of the solvent, the residue was dissolved in EtOAc (100 mL). The organic layer was washed with saturated NaHCO3 and brine, dried (Na2SO4), filtered, and purified by column chromatography to afford 3-(5-amino-3-t-butyl-1H-pyrazol-1-yl)benzonitrile (3.5 g, 73% yield).

후처리

  1. temperatureat reflux for 6 h
  2. customAfter removal of the solvent
  3. dissolutionthe residue was dissolved in EtOAc (100 mL)
  4. washThe organic layer was washed with saturated NaHCO3 and brine
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-6d00e7b6afe447f98b3eb79682f1b644
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163756B2

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