Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 4-hydrazinylbenzoate → ethyl 4-[5-amino-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 4-hydrazinylbenzoate | HCID 792992 | — |
| 반응물 | 4,4,4-Trifluoro-3-oxobutanenitrile | HCID 13843540 | — |
| 생성물 | ethyl 4-[5-amino-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzoate | HCID 58851394 | 91% |
반응 단계
Using the same method as Example QQ, 4-hydrazinobenzoic acid ethyl ester (From Example A82, 3.0 g, 16.6 mmol) and commercially available 1N NH 4,4,4-trifluoro-3-oxobutyronitrile (3.4 g, 24.9 mmol) were combined to afford ethyl 4-[5-amino-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzoate (4.5 g, 91% yield), which was used to the next reaction without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08163756B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-d0506939fe5648ebaa6b86dd2efa9695 |
| 출처 메모 | uspto-grants-2012_04 |