Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → 4-(Heptafluoropropylthio)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Aminothiophenol | HCID 14510 | — |
| 반응물 | Perfluoropropyl iodide | HCID 33977 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-(Heptafluoropropylthio)aniline | HCID 2052609 | 63.2% |
반응 단계
To 20 ml of an acetonitrile solution of 1.25 g of 4-aminothiophenol and 1.11 g of triethylamine was added 5.91 g of 1-iodoheptafluoro-n-propane. The resulting mixture was stirred at room temperature for 3 hours, diluted with ether, and then washed with aqueous 1N sodium hydroxide solution, purified by silica gel column chromatography using an eluent (development solvent; hexane:ethyl acetate=4:1) to obtain 1.85 g of the desired product (Yield: 63%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08163804B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-54274d3c1c6e4dd8a3b2e584862bc5bf |
| 출처 메모 | uspto-grants-2012_04 |