2-(1-Isopropyl-1H-imidazol-4-yl)ethanamine → N-((1S,2R,3S,4R)-4-{6-(2,2-Diphenyl-ethylamino)-2-[2-(1-isopropyl-1H-imidazol-4-yl)-ethylamino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-propionamide

참여 물질

역할	이름	HCID	투입량
반응물	2-(1-Isopropyl-1H-imidazol-4-yl)ethanamine	HCID 585835	—
반응물	(1S,4R)-4-(2,6-Dichloro-9H-purin-9-yl)cyclopent-2-en-1-ol	HCID 10378467	—
반응물	N-[(1S,2R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl]-propionamide	HCID 86622630	—
생성물	N-((1S,2R,3S,4R)-4-{6-(2,2-Diphenyl-ethylamino)-2-[2-(1-isopropyl-1H-imidazol-4-yl)-ethylamino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-propionamide	HCID 67019296	—

반응 단계

This compound is prepared from N-{(1S,2R,3S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide (compound of Example 4) and 2-(1-isopropyl-1H-imidazol-4-yl)-ethylamine using a procedure analogous to that of Example 9 for the desired salt. MS (ES+) m/e 638 (MH+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08163754B2
출처 데이터셋	uspto-grants-2012_04
ORD ID	ord-c82acaba57d54655b6917cb9dd3c73ee
출처 메모	uspto-grants-2012_04